![]() ![]() The theoretical and technological strategies used to develop the currently approved vaccines are diverse allowing for their preferential use in distinct groups of the human population. ![]() Since the identification of SARS-CoV-2 virus in 2019 and the emergence of Coronavirus disease of 2019 (COVID-19) as a global pandemic, there has been an upsurge of vaccine research and development worldwide with several vaccines that completed the clinical evaluation phases and were authorized for COVID-19. Our informatics workflow provides an invaluable tool to study post-vaccine adverse events on the systems biology level to suggest effective mechanism-based pharmacotherapy and/or suitable preventive measures. We also propose glucocorticoids as preferred treatments based on system biology evidence. We suggest that increasing the time interval between vaccine doses minimizes the risks of developing inflammatory adverse reactions. Systems biology results suggested a central role of interferon-gamma (INF-gamma) in the biological processes leading to cardiac adverse events, by impacting MAPK and JAK-STAT signaling pathways. The frequencies of cardiac adverse events were affected by vaccine, vaccine type, vaccine dose, sex, and age of the vaccinated individuals. Our results indicated that post-vaccine myocarditis and pericarditis were associated most frequently with mRNA COVID-19 vaccines followed by live or live-attenuated non-COVID-19 vaccines such as smallpox and anthrax vaccines. ![]() We introduce an informatics approach to study post-vaccine adverse events on the systems biology level to aid the prioritization of effective preventive measures and mechanism-based pharmacotherapy by integrating the analysis of adverse event reports from the Vaccine Adverse Event Reporting System (VAERS) with systems biology methods. Myocarditis and pericarditis have been linked recently to COVID-19 vaccines without exploring the underlying mechanisms, or compared to cardiac adverse events post-non-COVID-19 vaccines. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |